Affiliation:
1. RIKEN Center for Biosystems Dynamics Research, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
Abstract
Integrated stress response on the brain
During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gene expression. This process, known as the integrated stress response, is one of the most fundamental mechanisms of translational control conserved throughout eukaryotes. It is also a promising therapeutic target in neurodegenerative diseases and traumatic brain injury. Kashiwagi
et al.
report the cryo–electron microscopy and crystal structures and Kenner
et al.
report the cryo–electron microscopy structure of the guanine nucleotide exchange factor eIF2B in complex with eIF2 or phosphorylated eIF2. The structures of the eIF2•eIF2B complex reveal that the single phosphorylation modification on eIF2 changes how eIF2 binds to eIF2B and locks this enzyme into an inhibited complex.
Science
, this issue p.
495
, p.
491
Funder
Takeda Science Foundation
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
84 articles.
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