Polymersomes: Tough Vesicles Made from Diblock Copolymers-Reference-Cited by-同舟云学术

Polymersomes: Tough Vesicles Made from Diblock Copolymers

Published:1999-05-14 Issue:5417 Volume:284 Page:1143-1146
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Discher Bohdana M.¹,Won You-Yeon²,Ege David S.¹,Lee James C-M.¹,Bates Frank S.²,Discher Dennis E.¹,Hammer Daniel A.¹

Affiliation:

1. School of Engineering and Applied Science, and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO 40 -EE 37 ), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

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5. Reviewed in R. Lipowsky and E. Sackmann Eds. Structure and Dynamics of Membranes—From Cells to Vesicles vol. 1 of the Handbook of Biological Physics (Elsevier Science Amsterdam 1995). Note (as tabulated on page 19 of this reference) that for a generic plasma membrane such as that of the red blood cell about three-fourths of the phospholipids have acyl chains of lengths 16 18 or 20 carbon atoms. Note also (as indicated on pages 229 or 658 of the same reference) that a bilayer of lipids with chains of 16 or 18 carbon atoms in the biologically relevant disordered liquid phase (L α ) may be estimated to have a thickness d ≈ 3 nm.

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