Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1-Reference-Cited by-全球学者库

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

Published:2011-08-26 Issue:6046 Volume:333 Page:1154-1157
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Agrawal Nishant¹²,Frederick Mitchell J.³,Pickering Curtis R.³,Bettegowda Chetan²⁴,Chang Kyle⁵,Li Ryan J.¹,Fakhry Carole¹,Xie Tong-Xin³,Zhang Jiexin⁶,Wang Jing⁶,Zhang Nianxiang⁶,El-Naggar Adel K.⁷,Jasser Samar A.³,Weinstein John N.⁶,Treviño Lisa⁵,Drummond Jennifer A.⁵,Muzny Donna M.⁵,Wu Yuanqing⁵,Wood Laura D.⁸,Hruban Ralph H.⁸,Westra William H.⁸,Koch Wayne M.¹,Califano Joseph A.¹⁹,Gibbs Richard A.⁵⁹,Sidransky David¹,Vogelstein Bert²,Velculescu Victor E.²,Papadopoulos Nickolas²,Wheeler David A.⁵,Kinzler Kenneth W.²,Myers Jeffrey N.³

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

2. Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

3. Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.

4. Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

5. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

6. Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.

7. Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.

8. Department of Pathology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

9. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21204, USA.

Abstract

The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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4. The molecular biology of head and neck cancer

5. Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas;Berenson J. R.;Oncogene,1989

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