Structural basis for antibody-mediated neutralization of Lassa virus-Reference-Cited by-同舟云学术

Structural basis for antibody-mediated neutralization of Lassa virus

Published:2017-06-02 Issue:6341 Volume:356 Page:923-928
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hastie Kathryn M.¹^ORCID,Zandonatti Michelle A.¹^ORCID,Kleinfelter Lara M.²^ORCID,Heinrich Megan L.³,Rowland Megan M.³^ORCID,Chandran Kartik²^ORCID,Branco Luis M.³^ORCID,Robinson James E.⁴,Garry Robert F.³⁵^ORCID,Saphire Erica Ollmann¹⁶^ORCID

Affiliation:

1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.

3. Zalgen Labs, Germantown, MD, USA.

4. Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA, USA.

5. Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA.

6. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

Abstract

The crystal structure of an antibody–viral glycoprotein complex illuminates viral entry mechanisms and provides a blueprint for vaccine design.

Funder

National Institutes of Health

Burroughs Wellcome Fund

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference68 articles.

1. Lassa Fever in Post-Conflict Sierra Leone

2. Molecular Diagnostics for Lassa Fever at Irrua Specialist Teaching Hospital, Nigeria: Lessons Learnt from Two Years of Laboratory Operation

3. Lassa Fever in West Africa: Evidence for an Expanded Region of Endemicity

4. Genome Sequence of Lassa Virus Isolated from the First Domestically Acquired Case in Germany

5. Passive antibody therapy of Lassa fever in cynomolgus monkeys: importance of neutralizing antibody and Lassa virus strain

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