Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

Author:

Subbarao Kanta123,Klimov Alexander123,Katz Jacqueline123,Regnery Helen123,Lim Wilina123,Hall Henrietta123,Perdue Michael123,Swayne David123,Bender Catherine123,Huang Jing123,Hemphill Mark123,Rowe Thomas123,Shaw Michael123,Xu Xiyan123,Fukuda Keiji123,Cox Nancy123

Affiliation:

1. K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

2. W. Lim, Government Virus Unit, Queen Mary Hospital, Hong Kong, China.

3. M. Perdue and D. Swayne, Southeast Poultry Research Laboratory, Agriculture Research Service, U.S. Department of Agriculture, Athens, GA 30605, USA.

Abstract

An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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