Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1-Reference-Cited by-全球学者库

Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

Published:2009-09-04 Issue:5945 Volume:325 Page:1240-1243
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ahel Dragana¹,Hořejší Zuzana¹,Wiechens Nicola²,Polo Sophie E.³,Garcia-Wilson Elisa²,Ahel Ivan⁴⁵,Flynn Helen⁶,Skehel Mark⁶,West Stephen C.⁵,Jackson Stephen P.³,Owen-Hughes Tom²,Boulton Simon J.¹

Affiliation:

1. DNA Damage Response Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.

2. Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

3. The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

4. Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK.

5. Genetic Recombination Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.

6. Protein Analysis and Proteomics Laboratory, Clare Hall, London Research Institute, South Mimms EN6 3LD, UK.

Abstract

Damage, Signal, Maneuver Cellular processes, such as transcription and DNA repair, require modification and manipulation of chromosomally associated proteins by a diverse set of chromatin remodeling complexes. The mechanisms by which cells regulate chromatin remodeling are not completely understood. During the response elicited by DNA damage, the addition of poly(ADP-ribose) to chromatin is associated with chromatin decondensation, which is thought to promote efficient DNA repair. Ahel et al. (p. 1240 , published online 30 July 2009) have identified a chromatin remodeling enzyme as a DNA damage-response protein, which binds poly(ADP-ribose).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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4. The role of poly(ADP-ribose) in the DNA damage signaling network

5. Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

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