Conversion of human fibroblasts into functional cardiomyocytes by small molecules-Reference-Cited by-全球学者库

Conversion of human fibroblasts into functional cardiomyocytes by small molecules

Published:2016-06-03 Issue:6290 Volume:352 Page:1216-1220
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cao Nan¹²,Huang Yu¹,Zheng Jiashun³⁴,Spencer C. Ian¹,Zhang Yu¹²,Fu Ji-Dong⁵,Nie Baoming¹²,Xie Min¹²,Zhang Mingliang¹²,Wang Haixia¹²,Ma Tianhua¹²,Xu Tao¹²,Shi Guilai¹²,Srivastava Deepak¹⁶³,Ding Sheng¹²

Affiliation:

1. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

2. Department of Pharmaceutical Chemistry, University of California–San Francisco, San Francisco, CA 94158, USA.

3. Department of Biochemistry and Biophysics, University of California–San Francisco, San Francisco, CA 94158, USA.

4. California Institute for Quantitative Biosciences, University of California–San Francisco, San Francisco, CA 94158, USA.

5. Department of Medicine, Heart and Vascular Research Center, Case Western Reserve University, Cleveland, OH 44106, USA.

6. Department of Pediatrics, University of California–San Francisco, San Francisco, CA 94158, USA.

Abstract

Making cardiac cells from fibroblasts Reprogramming noncardiac cells into functional cardiomyocytes without any genetic manipulation could open up new avenues for cardiac regenerative therapies. Cao et al. identified a combination of nine small molecules that could epigenetically activate human fibroblasts, efficiently reprogramming them into chemically induced cardiomyocytes (ciCMs). The ciCMs contracted uniformly and resembled human cardiomyocytes. This method may be adapted for reprogramming multiple cell types and have important implications in regenerative medicine. Science , this issue p. 1216

Funder

California Institute for Regenerative Medicine (CIRM)

American Heart Association

CIRM

National Heart, Lung, and Blood Institute

National Institutes of Health

Roddenberry Foundation

Younger Family Foundation

Whittier Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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