Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat-Reference-Cited by-同舟云学术

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Published:2017-04-21 Issue:6335 Volume:356 Page:307-311
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Park Thomas J.¹^ORCID,Reznick Jane²^ORCID,Peterson Bethany L.¹^ORCID,Blass Gregory¹^ORCID,Omerbašić Damir²^ORCID,Bennett Nigel C.³,Kuich P. Henning J. L.⁴,Zasada Christin⁴^ORCID,Browe Brigitte M.¹^ORCID,Hamann Wiebke⁵^ORCID,Applegate Daniel T.¹^ORCID,Radke Michael H.⁵⁶^ORCID,Kosten Tetiana²,Lutermann Heike³^ORCID,Gavaghan Victoria¹^ORCID,Eigenbrod Ole²,Bégay Valérie²,Amoroso Vince G.¹^ORCID,Govind Vidya¹^ORCID,Minshall Richard D.⁷^ORCID,Smith Ewan St. J.⁸^ORCID,Larson John⁹,Gotthardt Michael⁵⁶,Kempa Stefan⁴^ORCID,Lewin Gary R.²¹⁰^ORCID

Affiliation:

1. Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.

2. Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

3. Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa.

4. Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

5. Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

6. German Centre for Cardiovascular Research (DZHK), Berlin, Germany.

7. Departments of Anesthesiology and Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.

8. Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.

9. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.

10. Excellence Cluster Neurocure, Charité Universitätsmedizin Berlin, Berlin, Germany.

Abstract

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248

Funder

National Science Foundation

National Institutes of Health

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

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4. The Metabolism of Fossorial Rodents: A Study of Convergence

5. Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic–hypercapnic stresses

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