Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

Author:

Bardelli Alberto1,Parsons D. Williams1,Silliman Natalie1,Ptak Janine1,Szabo Steve1,Saha Saurabh1,Markowitz Sanford1,Willson James K. V.1,Parmigiani Giovanni1,Kinzler Kenneth W.1,Vogelstein Bert1,Velculescu Victor E.1

Affiliation:

1. The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA. 3Howard Hughes Medical Institute and Ireland Cancer Center, University Hospitals of Cleveland and Case Western University, Cleveland, OH 44106, USA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference6 articles.

1. Oncogenic kinase signalling

2. The Protein Kinase Complement of the Human Genome

3. Materials and methods are available as supporting material on Science Online.

4. B. J. Druker, Cancer Cell1, 31. (2002).

5. Single-letter abbreviations for the amino acid residues are as follows: A Ala; C Cys; D Asp; E Glu; F Phe; G Gly; H His; I Ile; K Lys; L Leu; M Met; N Asn; P Pro; Q Gln; R Arg; S Ser; T Thr; V Val; W Trp; and Y Tyr.

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