A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1-Reference-Cited by-同舟云学术

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Published:2019-12-20 Issue:6472 Volume:366 Page:1522-1527
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Le Nours Jérôme¹²^ORCID,Gherardin Nicholas A.³⁴^ORCID,Ramarathinam Sri H.¹^ORCID,Awad Wael¹^ORCID,Wiede Florian¹⁵^ORCID,Gully Benjamin S.¹²,Khandokar Yogesh¹,Praveena T.¹,Wubben Jacinta M.¹,Sandow Jarrod J.⁶⁷,Webb Andrew I.⁶⁷^ORCID,von Borstel Anouk¹²^ORCID,Rice Michael T.¹²^ORCID,Redmond Samuel J.³,Seneviratna Rebecca³,Sandoval-Romero Maria L.¹^ORCID,Li Shihan³⁴,Souter Michael N. T.³,Eckle Sidonia B. G.³,Corbett Alexandra J.³^ORCID,Reid Hugh H.¹²^ORCID,Liu Ligong⁸⁹^ORCID,Fairlie David P.⁸⁹^ORCID,Giles Edward M.¹⁰^ORCID,Westall Glen P.¹¹¹²,Tothill Richard W.¹³¹⁴^ORCID,Davey Martin S.¹²^ORCID,Berry Richard¹²,Tiganis Tony¹⁵^ORCID,McCluskey James³^ORCID,Pellicci Daniel G.³⁴^ORCID,Purcell Anthony W.¹^ORCID,Uldrich Adam P.³⁴^ORCID,Godfrey Dale I.³⁴^ORCID,Rossjohn Jamie¹²¹⁵^ORCID

Affiliation:

1. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

2. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.

3. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.

4. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Victoria 3010, Australia.

5. Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.

6. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

7. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia.

8. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

9. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Queensland, Brisbane, Queensland 4072, Australia.

10. Department of Paediatrics, Monash University, and Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medicine, Clayton, Victoria 3168, Australia.

11. Lung Transplant Service, Alfred Hospital, Melbourne, Victoria 3004, Australia.

12. Department of Medicine, Monash University, Clayton, Victoria 3800, Australia.

13. Department of Clinical Pathology and Centre for Cancer Research, University of Melbourne, Parkville, Victoria 3052, Australia.

14. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3000, Australia.

15. Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.

Abstract

A different way for γδ T cells to bind The ligands bound by γδ T cell receptors (TCRs) are less well characterized than those of their αβ TCR cousins, which are antigens presented by major histocompatibility complex (MHC) and related proteins. Le Nours et al. identified a phenotypically diverse γδ T cell subset in human tissues that reacts to MHC-related protein 1 (MR1), which presents vitamin B derivatives. A crystal structure of a γδ TCR–MR1–antigen complex revealed that some of these TCRs can bind underneath the MR1 antigen-binding cleft instead of recognizing the presented antigen. This work thus uncovers an additional ligand for γδ T cells and reconceptualizes the nature of T cell antigen recognition. Science , this issue p. 1522

Funder

Australian Research Council

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

2. MR1 presents microbial vitamin B metabolites to MAIT cells

3. T-cell activation by transitory neo-antigens derived from distinct microbial pathways

4. Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

5. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors

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