Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants-Reference-Cited by-全球学者库

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Published:2003-08-08 Issue:5634 Volume:301 Page:805-809
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Santarelli Luca¹²³⁴,Saxe Michael¹²³⁴,Gross Cornelius¹²³⁴,Surget Alexandre¹²³⁴,Battaglia Fortunato¹²³⁴,Dulawa Stephanie¹²³⁴,Weisstaub Noelia¹²³⁴,Lee James¹²³⁴,Duman Ronald¹²³⁴,Arancio Ottavio¹²³⁴,Belzung Catherine¹²³⁴,Hen René¹²³⁴

Affiliation:

1. Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

2. Psychobiologie des Emotions, Université François Rabelais, Tours 37200, France.

3. Nathan Kline Research Institute, New York University School of Medicine, New York, NY 10016, USA.

4. Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT 06508, USA.

Abstract

Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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