A Genomic Regulatory Network for Development-Reference-Cited by-同舟云学术

A Genomic Regulatory Network for Development

Published:2002-03 Issue:5560 Volume:295 Page:1669-1678
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Davidson Eric H.¹,Rast Jonathan P.¹,Oliveri Paola¹,Ransick Andrew¹,Calestani Cristina¹,Yuh Chiou-Hwa¹,Minokawa Takuya¹,Amore Gabriele¹,Hinman Veronica¹,Arenas-Mena César¹,Otim Ochan¹,Brown C. Titus¹,Livi Carolina B.¹,Lee Pei Yun¹,Revilla Roger¹,Rust Alistair G.²,Pan Zheng jun²,Schilstra Maria J.²,Clarke Peter J. C.²,Arnone Maria I.³,Rowen Lee⁴,Cameron R. Andrew¹,McClay David R.⁵,Hood Leroy⁴,Bolouri Hamid²

Affiliation:

1. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

2. Science and Technology Research Centre, University of Hertfordshire, AL10 9AB, UK.

3. Stazione Zoologica Anton Dohrn, 80121 Naples, Italy.

4. Institute for Systems Biology, Seattle, WA 98105, USA.

5. Department of Zoology, Duke University, Durham, NC 27708–0325, USA.

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference70 articles.

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2. Endo16, a lineage-specific protein of the sea urchin embryo, is first expressed just prior to gastrulation

3. Whole mount in situ hybridization shows Endo 16 to be a marker for the vegetal plate territory in sea urchin embryos

4. Endo16, a Large Multidomain Protein Found on the Surface and ECM of Endodermal Cells during Sea Urchin Gastrulation, Binds Calcium

5. Genomic Cis-Regulatory Logic: Experimental and Computational Analysis of a Sea Urchin Gene

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