Affiliation:
1. Simpson Memorial Research Institute, Division of Hematology and Oncology, University of Michigan, Ann Arbor 48109
Abstract
Human neutrophils were found to generate an unusual class of oxidants with a half-life of approximately 18 hours and with characteristics similar to, if not identical with, those of
N
-chloroamines. These neutrophil-derived
N
-chloroamines have sufficient oxidizing potential to attack sulfhydryl- or thioether-containing compounds and can react with both a methionine-containing chemotactic peptide and a plasma protease inhibitor. As judged by their stability and selective reactivity, the
N
-chloroamines generated by stimulated neutrophils may play an important role in the local and systemic regulation of inflammatory events in vivo.
Publisher
American Association for the Advancement of Science (AAAS)
Reference11 articles.
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