Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes-Reference-Cited by-同舟云学术

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

Published:2019-07-19 Issue:6450 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nortley Ross¹^ORCID,Korte Nils¹^ORCID,Izquierdo Pablo¹^ORCID,Hirunpattarasilp Chanawee¹^ORCID,Mishra Anusha²^ORCID,Jaunmuktane Zane³⁴^ORCID,Kyrargyri Vasiliki¹,Pfeiffer Thomas¹^ORCID,Khennouf Lila¹^ORCID,Madry Christian¹^ORCID,Gong Hui¹^ORCID,Richard-Loendt Angela³^ORCID,Huang Wenhui⁵^ORCID,Saito Takashi⁶^ORCID,Saido Takaomi C.⁶^ORCID,Brandner Sebastian³⁷^ORCID,Sethi Huma⁸,Attwell David¹^ORCID

Affiliation:

1. Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.

2. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.

3. Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.

4. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.

5. Molecular Physiology, CIPMM, University of Saarland, D-66421 Homburg, Germany.

6. Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.

7. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.

8. Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.

Abstract

Pericytes put the squeeze on cognition Like a computer, the brain needs a reliable source of power, which is provided as oxygen and glucose in the blood. However, in many neurological disorders this energy supply is disrupted. Brain blood flow is controlled by adjustment of the diameters of the vessels supplying the blood. Nortley et al. found that, both in humans developing Alzheimer's disease (AD) and in a mouse model of AD, brain capillaries become squeezed by pericytes (see the Perspective by Liesz). By defining the underlying mechanism, they suggest potential targets for therapy in early AD. Science , this issue p. eaav9518 ; see also p. 223

Funder

Wellcome Trust

European Research Council

Deutsche Forschungsgemeinschaft

EMBO

Lundbeckfonden

national institute of health research

Leonard Wolfson Experimental Neurology Centre

BBSRC

Chulabhorn Royal Academy

Publisher

American Association for the Advancement of Science (AAAS)