A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy-Reference-Cited by-同舟云学术

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Published:2013-04-19 Issue:6130 Volume:340 Page:350-353
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Barde Isabelle¹,Rauwel Benjamin¹,Marin-Florez Ray Marcel²,Corsinotti Andrea¹,Laurenti Elisa¹,Verp Sonia¹,Offner Sandra¹,Marquis Julien¹,Kapopoulou Adamandia¹,Vanicek Jiri²,Trono Didier¹

Affiliation:

1. School of Life Sciences and Frontiers in Genetics Program, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

2. School of Basic Sciences, EPFL, 1015 Lausanne, Switzerland.

Abstract

Red in Cell and Marrow About one hundred billion new red cells are released every day from the adult human bone marrow—the result of a complex differentiation pathway. Barde et al. (p. 350 , published online 14 March) show that an essential step in this process, the elimination of mitochondria from maturing erythroblasts through mitophagy, is controlled through the timely induction of specific members of the large family of KRAB-containing zinc finger proteins (KRAB-ZFPs), which, together with their cofactor KAP1, repress the expression of micro-RNAs targeting the transcripts of mitophagy effector genes. This multilayered and combinatorial regulation system provides a level of modularity that may be shared by other physiological processes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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