Affiliation:
1. The author is at the Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK.
Abstract
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.
Publisher
American Association for the Advancement of Science (AAAS)
Reference76 articles.
1. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
2. A. Ridley H. F. Paterson C. Johnston D. Diekmann A. Hall ibid. p. 401.
3. Nobes C. D., Hall A., ibid. 81, 53 (1995).
4. Kozma R., Ahmed S., Best A., Lim L., Mol. Cell. Biol. 15, 1942 (1995).
5. Kozma R., Sarner S., Ahmed S., Lim L., ibid. 17, 1201 (1997).
Cited by
5392 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献