Affiliation:
1. Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Abstract
Resident memory T cells sound the alarm
Immunological memory protects against reinfection. Resident memory T cells (T
RM
) are long-lived and remain in the tissues where they first encountered a pathogen (see the Perspective by Carbone and Gebhardt). Schenkel
et al.
and Ariotti
et al.
found that CD8
+
T
RM
cells act like first responders in the female reproductive tissue or the skin of mice upon antigen reencounter. By secreting inflammatory proteins, T
RM
cells rapidly activated local immune cells to respond, so much so that they protected against infection with an unrelated pathogen. Iijima and Iwasaki found that CD4
+
T
RM
cells protected mice against reinfection with intravaginal herpes simplex virus 2.
Science
, this issue p.
98
, p.
101
, p.
93
; see also p.
40
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
334 articles.
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