Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition-Reference-Cited by-同舟云学术

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

Published:2019-02 Issue:6426 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ballinger Elaine¹^ORCID,Mosior John²^ORCID,Hartman Travis³^ORCID,Burns-Huang Kristin¹,Gold Ben¹^ORCID,Morris Roxanne³^ORCID,Goullieux Laurent⁴,Blanc Isabelle⁴,Vaubourgeix Julien¹^ORCID,Lagrange Sophie⁴,Fraisse Laurent⁴,Sans Stéphanie⁴^ORCID,Couturier Cedric⁴^ORCID,Bacqué Eric⁴^ORCID,Rhee Kyu³,Scarry Sarah M.⁵^ORCID,Aubé Jeffrey⁵^ORCID,Yang Guangbin⁶^ORCID,Ouerfelli Ouathek⁶^ORCID,Schnappinger Dirk¹^ORCID,Ioerger Thomas R.¹^ORCID,Engelhart Curtis A.¹^ORCID,McConnell Jennifer A.¹^ORCID,McAulay Kathrine¹^ORCID,Fay Allison⁷^ORCID,Roubert Christine⁴,Sacchettini James²^ORCID,Nathan Carl¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.

2. Departments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX, USA.

3. Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

4. Infectious Diseases Therapeutic Area, Sanofi, Marcy-l’Étoile, France.

5. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.

6. Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

7. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Welch Foundation

Abby and Howard P. Milstein Program in Chemical Biology and Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Molecular mechanisms that confer antibacterial drug resistance

2. Kunkel Lecture: Fundamental immunodeficiency and its correction

3. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

4. Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

5. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

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