A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A-Reference-Cited by-同舟云学术

A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A

Published:2007-02-09 Issue:5813 Volume:315 Page:820-825
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kawaguchi Riki¹²³⁴⁵,Yu Jiamei¹²³⁴⁵,Honda Jane¹²³⁴⁵,Hu Jane¹²³⁴⁵,Whitelegge Julian¹²³⁴⁵,Ping Peipei¹²³⁴⁵,Wiita Patrick¹²³⁴⁵,Bok Dean¹²³⁴⁵,Sun Hui¹²³⁴⁵

Affiliation:

1. Department of Physiology, David Geffen School of Medicine at UCLA, 650 Charles E. Young Drive South, Los Angeles, CA 90095, USA.

2. Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, 100 Stein Plaza, 650 Charles E. Young Drive South, Los Angeles, CA 90095, USA.

3. Pasarow Mass Spectrometry Laboratory, Semel Institute, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Los Angeles, CA 90024, USA.

4. Brain Research Institute, UCLA, Los Angeles, CA 90095, USA.

5. Department of Medicine, David Geffen School of Medicine at UCLA, 650 Charles E. Young Drive South, Los Angeles, CA 90095, USA.

Abstract

Vitamin A has diverse biological functions. It is transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechanism by which vitamin A is absorbed by cells from the vitamin A–RBP complex is not clearly understood. We identified in bovine retinal pigment epithelium cells STRA6, a multitransmembrane domain protein, as a specific membrane receptor for RBP. STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A–RBP complex. It is widely expressed in embryonic development and in adult organ systems. The RBP receptor represents a major physiological mediator of cellular vitamin A uptake.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. J. E. Dowling, Sci. Am.215, 78 (1966).

2. R. M. Evans, Harvey Lect.90, 105 (1994).

3. FUNCTION OF RETINOID NUCLEAR RECEPTORS: Lessons from Genetic and Pharmacological Dissections of the Retinoic Acid Signaling Pathway During Mouse Embryogenesis

4. D. S. Goodman, in The Retinoids, M. B. Sporn, A. B. Boberts, D. S. Goodman, Eds. (Academic Press, New York, 1984), vol. 2, pp. 41–88.

5. Transport and Storage of Vitamin A

Cited by 648 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Retinoic acid signaling in development and differentiation commitment and its regulatory topology;Chemico-Biological Interactions;2024-01

2. Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway;Journal of Ethnopharmacology;2024-01

3. Retinoids: Mechanisms of Action in Neuronal Cell Fate Acquisition;Life;2023-11-29

4. The etiology of congenital diaphragmatic hernia: the retinoid hypothesis 20 years later;Pediatric Research;2023-11-21

5. Regulation of circulating thyroid hormone levels by hypothalamic tanycytes and hypophysial pars tuberalis‐specific cells and their morphological and gene‐ and protein‐expression changes under different photoperiods;Journal of Comparative Neurology;2023-11-08