The Genomic Sequence of the Accidental Pathogen Legionella pneumophila-Reference-Cited by-全球学者库

The Genomic Sequence of the Accidental Pathogen Legionella pneumophila

Published:2004-09-24 Issue:5692 Volume:305 Page:1966-1968
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chien Minchen¹²³⁴⁵,Morozova Irina¹²³⁴⁵,Shi Shundi¹²³⁴⁵,Sheng Huitao¹²³⁴⁵,Chen Jing¹²³⁴⁵,Gomez Shawn M.¹²³⁴⁵,Asamani Gifty¹²³⁴⁵,Hill Kendra¹²³⁴⁵,Nuara John¹²³⁴⁵,Feder Marc¹²³⁴⁵,Rineer Justin¹²³⁴⁵,Greenberg Joseph J.¹²³⁴⁵,Steshenko Valeria¹²³⁴⁵,Park Samantha H.¹²³⁴⁵,Zhao Baohui¹²³⁴⁵,Teplitskaya Elita¹²³⁴⁵,Edwards John R.¹²³⁴⁵,Pampou Sergey¹²³⁴⁵,Georghiou Anthi¹²³⁴⁵,Chou I.-Chun¹²³⁴⁵,Iannuccilli William¹²³⁴⁵,Ulz Michael E.¹²³⁴⁵,Kim Dae H.¹²³⁴⁵,Geringer-Sameth Alex¹²³⁴⁵,Goldsberry Curtis¹²³⁴⁵,Morozov Pavel¹²³⁴⁵,Fischer Stuart G.¹²³⁴⁵,Segal Gil¹²³⁴⁵,Qu Xiaoyan¹²³⁴⁵,Rzhetsky Andrey¹²³⁴⁵,Zhang Peisen¹²³⁴⁵,Cayanis Eftihia¹²³⁴⁵,De Jong Pieter J.¹²³⁴⁵,Ju Jingyue¹²³⁴⁵,Kalachikov Sergey¹²³⁴⁵,Shuman Howard A.¹²³⁴⁵,Russo James J.¹²³⁴⁵

Affiliation:

1. Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

2. Unite de Biochimie et Biologie Moleculaire des Insectes, Institut Pasteur, Paris 75015 France.

3. BACPAC Resources Laboratory, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

4. Department of Chemical Engineering, The Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10027, USA.

5. Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.

Abstract

We present the genomic sequence of Legionella pneumophila , the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45âkilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella 's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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