Acoel genome reveals the regulatory landscape of whole-body regeneration-Reference-Cited by-同舟云学术

Acoel genome reveals the regulatory landscape of whole-body regeneration

Published:2019-03-15 Issue:6432 Volume:363 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gehrke Andrew R.¹^ORCID,Neverett Emily¹,Luo Yi-Jyun¹^ORCID,Brandt Alexander²,Ricci Lorenzo¹^ORCID,Hulett Ryan E.¹^ORCID,Gompers Annika¹^ORCID,Ruby J. Graham³,Rokhsar Daniel S.⁴^ORCID,Reddien Peter W.⁵^ORCID,Srivastava Mansi¹⁶^ORCID

Affiliation:

1. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

2. Department of Chemistry, University of California, Berkeley, CA 94703, USA.

3. Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

4. Department of Molecular and Cell Biology, University of California, Berkeley, CA 94703, USA.

5. Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.

6. Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Acoel-regeneration regulatory landscapes Some animals, including some types of worms, can undergo whole-body regeneration and replace virtually any missing cell type. Gehrke et al. sequenced and assembled the genome of Hofstenia miamia , a regenerative acoel worm species (see the Perspective by Alonge and Schatz). They identified a variable motif corresponding to regulation of the early growth response ( egr ) gene that was involved in regeneration. RNA interference experiments and validation in a second species showed that the protein Egr is a pioneer factor that stimulates regeneration. Science , this issue p. eaau6173 ; see also p. 1152

Funder

National Science Foundation

Searle Scholars Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Evolution of animal regeneration: re-emergence of a field

2. A molecular wound response program associated with regeneration initiation in planarians

3. A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians

4. (Neo)blast from the past: new insights into planarian stem cell lineages

5. Smed- β catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

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