Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

Author:

Lombardi Vincent C.1,Ruscetti Francis W.2,Das Gupta Jaydip3,Pfost Max A.1,Hagen Kathryn S.1,Peterson Daniel L.1,Ruscetti Sandra K.4,Bagni Rachel K.5,Petrow-Sadowski Cari6,Gold Bert2,Dean Michael2,Silverman Robert H.3,Mikovits Judy A.1

Affiliation:

1. Whittemore Peterson Institute, Reno, NV 89557, USA.

2. Laboratory of Experimental Immunology, National Cancer Institute–Frederick, Frederick, MD 21701, USA.

3. Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

4. Laboratory of Cancer Prevention, National Cancer Institute–Frederick, Frederick, MD 21701, USA.

5. Advanced Technology Program, National Cancer Institute–Frederick, Frederick, MD 21701, USA.

6. Basic Research Program, Scientific Applications International Corporation, National Cancer Institute–Frederick, Frederick, MD 21701, USA.

Abstract

Viral Link to Chronic Fatigue Chronic fatigue syndrome (CFS) is a complex and debilitating disorder that is often linked to immune system dysfunction but whose cause(s) remain mysterious. Lombardi et al. (p. 585 , published online 8 October; see the Perspective by Coffin and Stoye ) now present a tantalizing new lead. In blood samples from 101 patients with well-documented CFS, over two-thirds (68) contained DNA from a recently described human gammaretrovirus, xenotropic murine leukemia virus–related virus (XMRV), which possesses sequence similarity to a murine leukemia virus. Cell culture assays confirmed that XMRV derived from CFS patient plasma and from T and B lymphocytes was infectious. Although the correlation with CFS is striking, whether the virus plays a causal role in the disorder remains to be determined. Interestingly, nearly 4% of the 218 healthy donors tested were positive for XMRV, which suggests that this virus—whose pathogenic potential is unknown—may be present in a significant proportion of the general population.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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