Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense
Author:
Affiliation:
1. Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
2. Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference35 articles.
1. The Biochemistry and Cell Biology of Antigen Processing and Presentation
2. Positive Selection of Thymocytes
3. Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection
4. Pathogen-Based Models Favoring MHC Genetic Diversity
5. A "Minimal Essential Mhc" and an "Unrecognized Mhc": Two Extremes in Selection for Polymorphism
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