The Genetic Landscape of the Childhood Cancer Medulloblastoma

Author:

Parsons D. Williams12,Li Meng1,Zhang Xiaosong1,Jones Siân1,Leary Rebecca J.1,Lin Jimmy Cheng-Ho1,Boca Simina M.3,Carter Hannah4,Samayoa Josue4,Bettegowda Chetan15,Gallia Gary L.5,Jallo George I.5,Binder Zev A.5,Nikolsky Yuri6,Hartigan James7,Smith Doug R.7,Gerhard Daniela S.8,Fults Daniel W.9,VandenBerg Scott10,Berger Mitchel S.11,Marie Suely Kazue Nagahashi12,Shinjo Sueli Mieko Oba12,Clara Carlos13,Phillips Peter C.14,Minturn Jane E.14,Biegel Jaclyn A.14,Judkins Alexander R.15,Resnick Adam C.16,Storm Phillip B.16,Curran Tom15,He Yiping17,Rasheed B. Ahmed17,Friedman Henry S.17,Keir Stephen T.17,McLendon Roger17,Northcott Paul A.18,Taylor Michael D.18,Burger Peter C.19,Riggins Gregory J.15,Karchin Rachel4,Parmigiani Giovanni20,Bigner Darell D.17,Yan Hai17,Papadopoulos Nick1,Vogelstein Bert1,Kinzler Kenneth W.1,Velculescu Victor E.1

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

2. Texas Children’s Cancer Center and Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston TX 77030, USA.

3. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

4. Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21218, USA.

5. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

6. GeneGo, Inc., St. Joseph, St. Joseph, MI 49085, USA.

7. Beckman Coulter Genomics, Inc., Danvers, MA 01923, USA.

8. Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

9. Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

10. Department of Pathology, Division of Neuropathology, University of California–San Diego, San Diego, CA, USA.

11. Department of Neurological Surgery, University of California–San Francisco, San Francisco, CA 94143, USA.

12. Department of Neurology, School of Medicine of University of Sao Paulo, Sao Paulo, Brazil.

13. Pio XII Foundation, Barretos Cancer Hospital, Sao Paulo, Brazil.

14. Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

15. Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

16. Division of Neurosurgery, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

17. The Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

18. Division of Neurosurgery and Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario M5G1L7, Canada.

19. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

20. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.

Abstract

Genomic analysis of a childhood cancer reveals markedly fewer mutations than what is typically seen in adult cancers.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. F. Giangaspero et al . in WHO Classification of the Central Nervous System H. O. D. N. Louis O. D. Wiestler W. K. Cavenee Eds. (WHO Press Lyon France 2007).

2. Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification

3. Medulloblastoma Comprises Four Distinct Molecular Variants

4. Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations

5. Bigner S. H., et al.., Cancer Res. 50, 2347 (1990).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3