The 5300-year-old Helicobacter pylori genome of the Iceman

Author:

Maixner Frank1,Krause-Kyora Ben2,Turaev Dmitrij3,Herbig Alexander45,Hoopmann Michael R.6,Hallows Janice L.6,Kusebauch Ulrike6,Vigl Eduard Egarter7,Malfertheiner Peter8,Megraud Francis9,O’Sullivan Niall1,Cipollini Giovanna1,Coia Valentina1,Samadelli Marco1,Engstrand Lars10,Linz Bodo11,Moritz Robert L.6,Grimm Rudolf12,Krause Johannes45,Nebel Almut2,Moodley Yoshan1314,Rattei Thomas3,Zink Albert1

Affiliation:

1. Institute for Mummies and the Iceman, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy.

2. Institute of Clinical Molecular Biology, Kiel University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

3. CUBE–Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.

4. Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 23, 72072 Tübingen, Germany.

5. Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, 07745 Jena, Germany.

6. Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.

7. Scuola Superiore Sanitaria Provinciale “Claudiana,” Via Lorenz Böhler 13, 39100 Bolzano, Italy.

8. Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany.

9. Université de Bordeaux, Centre National de Référence des Helicobacters et Campylobacters and INSERM U853, 146 rue Léo Saignat, 33076 Bordeaux, France.

10. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 141 83 Stockholm, Sweden.

11. Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.

12. Robert Mondavi Institute for Food Science, University of California, Davis, CA 95616, USA.

13. Department of Zoology, University of Venda, Private Bag X5050, Thohoyandou 0950, Republic of South Africa.

14. Department of Integrative Biology and Evolution, Konrad Lorenz Institute for Ethology, University of Veterinary Medicine Vienna, Savoyenstrasse 1a, 1160 Vienna, Austria.

Abstract

Stomach ache for a European mummy Five thousand years ago in the European Alps, a man was shot by an arrow, then clubbed to death. His body was subsequently mummified by ice until glacier retreat exhumed him in 1991. Subsequently, this ancient corpse has provided a trove of intriguing information about copper-age Europeans. Now, Maixner et al. have identified the human pathogen Helicobacter pylori within the mummy's stomach contents. The strain the “Iceman” hosted appears to most closely resemble pathogenic Asian strains found today in Central and Southern Asia. Science , this issue p. 162

Funder

South Tyrolean

Ernst Ludwig Ehrlich Studienwerk

European Research Council

National Institutes of Health

National Institute of General Medical Sciences

Center for Systems Biology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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