TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification-Reference-Cited by-同舟云学术

TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification

Published:2012-08-31 Issue:6098 Volume:337 Page:1111-1115
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Oldenburg Marina¹,Krüger Anne¹,Ferstl Ruth²,Kaufmann Andreas³,Nees Gernot³,Sigmund Anna¹,Bathke Barbara⁴,Lauterbach Henning⁴,Suter Mark⁴⁵,Dreher Stefan²,Koedel Uwe⁶,Akira Shizuo⁷,Kawai Taro⁷,Buer Jan¹,Wagner Hermann²,Bauer Stefan³,Hochrein Hubertus⁴,Kirschning Carsten J.¹

Affiliation:

1. Institute of Medical Microbiology, University of Duisburg-Essen, 45147 Essen, Germany.

2. Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany.

3. Institute for Immunology, Philipps University of Marburg, 35043 Marburg, Germany.

4. Department of Research Immunology, Bavarian Nordic GmbH, 82152 Martinsried, Germany.

5. Institute of Virology, University of Zurich, 8006 Zurich, Switzerland.

6. Department of Neurology, Clinic of the University of Munich, 81377 Munich, Germany.

7. World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

Abstract

A Double Escapee Toll-like receptors (TLRs)—TLR2 and TLR7—are thought to contribute to the sensing of Gram-positive bacteria like Staphylococcus aureus and Streptococcus pneumoniae by the immune system. Mice deficient in these receptors, however, are still sensitive to infection with these bacteria. Oldenburg et al. (p. 1111 , published online 19 July) demonstrate that TLR13 also plays a role in detecting Gram-positive bacteria. TLR13 recognized a conserved region in the peptidyl transferase loop of bacterial 23S ribosomal RNA. Intriguingly, this same sequence is modified by specific methyltransferases that confer resistance to erythromycin. Indeed, erythromycin-resistant bacteria were no longer detectible by TLR13.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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