African Origin of Modern Humans in East Asia: A Tale of 12,000 Y Chromosomes

Author:

Ke Yuehai1,Su Bing123,Song Xiufeng1,Lu Daru1,Chen Lifeng1,Li Hongyu1,Qi Chunjian1,Marzuki Sangkot4,Deka Ranjan5,Underhill Peter6,Xiao Chunjie7,Shriver Mark8,Lell Jeff9,Wallace Douglas9,Wells R Spencer10,Seielstad Mark11,Oefner Peter6,Zhu Dingliang12,Jin Jianzhong1,Huang Wei1213,Chakraborty Ranajit3,Chen Zhu1213,Jin Li1313

Affiliation:

1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China 200443, and Morgan-Tan International Center for Life Sciences, Shanghai, China.

2. Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, China.

3. Human Genetics Center, University of Texas–Houston, 1200 Herman Pressler E547, Houston, TX 77030, USA.

4. Eijkman Institute for Molecular Biology, Jakarta, Indonesia.

5. Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267, USA.

6. Department of Genetics, Stanford University, Stanford, CA 94305, USA.

7. Department of Biology, Yunnan University, Kunming, China.

8. Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.

9. Center for Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

10. Wellcome Trust Center for Human Genetics, University of Oxford, UK.

11. Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA.

12. Shanghai Second Medical University, Shanghai, China.

13. National Human Genome Center at Shanghai, China.

Abstract

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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