BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF-Reference-Cited by-同舟云学术

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Published:2001-09-14 Issue:5537 Volume:293 Page:2108-2111
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thompson Jeffrey S.¹,Bixler Sarah A.¹,Qian Fang¹,Vora Kalpit¹,Scott Martin L.¹,Cachero Teresa G.¹,Hession Catherine¹,Schneider Pascal²,Sizing Irene D.¹,Mullen Colleen¹,Strauch Kathy¹,Zafari Mohammad¹,Benjamin Christopher D.¹,Tschopp Jurg²,Browning Jeffrey L.¹,Ambrose Christine¹

Affiliation:

1. Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.

2. The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.

Abstract

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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