Permuted tRNA Genes Expressed via a Circular RNA Intermediate in Cyanidioschyzon merolae-Reference-Cited by-同舟云学术

Permuted tRNA Genes Expressed via a Circular RNA Intermediate in Cyanidioschyzon merolae

Published:2007-10-19 Issue:5849 Volume:318 Page:450-453
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Soma Akiko¹²³⁴⁵,Onodera Akinori¹²³⁴⁵,Sugahara Junichi¹²³⁴⁵,Kanai Akio¹²³⁴⁵,Yachie Nozomu¹²³⁴⁵,Tomita Masaru¹²³⁴⁵,Kawamura Fujio¹²³⁴⁵,Sekine Yasuhiko¹²³⁴⁵

Affiliation:

1. Department of Life Science, College of Science, Rikkyo (St. Paul's) University, Toshima, Tokyo 171-8501, Japan.

2. Institute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.

3. Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, 252-8520, Japan.

4. Faculty of Environment and Information Studies, Keio University, Fujisawa, 252-8520, Japan.

5. Research Information Center for Extremophile, Rikkyo (St. Paul's) University, Toshima, Tokyo 171-8501, Japan.

Abstract

A computational analysis of the nuclear genome of a red alga, Cyanidioschyzon merolae , identified 11 transfer RNA (tRNA) genes in which the 3′ half of the tRNA lies upstream of the 5′ half in the genome. We verified that these genes are expressed and produce mature tRNAs that are aminoacylated. Analysis of tRNA-processing intermediates for these genes indicates an unusual processing pathway in which the termini of the tRNA precursor are ligated, resulting in formation of a characteristic circular RNA intermediate that is then processed at the acceptor stem to generate the correct termini.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference20 articles.

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5. Materials and methods are available on Science Online.

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