Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior

Author:

Ferenczi Emily A.12,Zalocusky Kelly A.12,Liston Conor3,Grosenick Logan12,Warden Melissa R.4,Amatya Debha1,Katovich Kiefer5,Mehta Hershel5,Patenaude Brian6,Ramakrishnan Charu1,Kalanithi Paul7,Etkin Amit6,Knutson Brian5,Glover Gary H.8,Deisseroth Karl149

Affiliation:

1. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

2. Neurosciences Program, Stanford University, Stanford, CA 94305, USA.

3. Brain Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA.

4. Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.

5. Department of Psychology, Stanford University, Stanford, CA 94305, USA.

6. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

7. Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

8. Department of Radiology, Stanford University, Stanford, CA, 94305, USA.

9. Howard Hughes Medical Institute, Stanford University, Stanford, CA, 94305, USA.

Abstract

A way to modulate reward-seeking Which brain regions are causally involved in reward-related behavior? Ferenczi et al. combined focal, cell type-specific, optogenetic manipulations with brain imaging, behavioral testing, and in vivo electrophysiology (see the Perspective by Robbins). Stimulation of midbrain dopamine neurons increased activity in a brain region called the striatum and was correlated with reward-seeking across individual animals. However, elevated excitability of an area called the medial prefrontal cortex reduced both striatal responses to the stimulation of dopamine neurons and the behavioral drive to seek the stimulation of dopamine neurons. Finally, modulating the excitability of medial prefrontal cortex pyramidal neurons drove changes in neural circuit synchrony, as well as corresponding anhedonic behavior. These observations resemble imaging and clinical phenotypes observed in human depression, addiction, and schizophrenia. Science , this issue p. 10.1126/science.aac9698 ; see also p. 10.1126/science.aad9698

Funder

Defense Advanced Research Projects Agency

National Institute of Mental Health

National Institute on Drug Abuse (NIDA)

NSF

Simons Foundation

Gatsby Foundation

Wiegers Family Fund

Grosfeld

Reeves

Snyder

Woo

Albert Yu and Mary Bechman Foundations

NIDA

NARSAD

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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