Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle-Reference-Cited by-同舟云学术

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

Published:2018-06-15 Issue:6394 Volume:360 Page:1235-1239
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Caputi Lorenzo¹^ORCID,Franke Jakob¹^ORCID,Farrow Scott C.¹^ORCID,Chung Khoa¹^ORCID,Payne Richard M. E.¹^ORCID,Nguyen Trinh-Don¹^ORCID,Dang Thu-Thuy T.¹^ORCID,Soares Teto Carqueijeiro Inês²^ORCID,Koudounas Konstantinos²^ORCID,Dugé de Bernonville Thomas²^ORCID,Ameyaw Belinda¹^ORCID,Jones D. Marc¹^ORCID,Vieira Ivo Jose Curcino³^ORCID,Courdavault Vincent²^ORCID,O’Connor Sarah E.¹^ORCID

Affiliation:

1. Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

2. Université de Tours, EA2106 Biomolécules et Biotechnologies Végétales, Parc de Grandmont 37200 Tours, France.

3. Laboratorio de Ciencias Quimicas-UENF-Campos dos Goytacazes-RJ, 28013-602, Brazil.

Abstract

How to make bioactive alkaloids Vinblastine and vincristine are important, expensive anticancer agents that are produced by dimerization of the plant-derived alkaloids catharanthine and vindoline. The enzymes that transform tabersonine into vindoline are known; however, the mechanism by which the scaffolds of catharanthine and tabersonine are generated has been a mystery. Caputi et al. now describe the biosynthetic genes and corresponding enzymes responsible. This resolves a long-standing question of how plant alkaloid scaffolds are synthesized, which is important not only for vinblastine and vincristine biosynthesis, but also for understanding the many other biologically active alkaloids found throughout nature. Science , this issue p. 1235

Funder

Biotechnology and Biological Sciences Research Council

European Research Council

Région Centre-Val de Loire

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Chemistry and biology of monoterpene indole alkaloid biosynthesis

2. Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine

3. S. Vonny V. De Luca “Towards complete elucidation of monoterpene indole alkaloid biosynthesis pathway: Catharanthus roseus as a pioneer system”in Advances in Botanical Research (Elsevier 2013) pp. 1–37.