Mass spectrometry imaging with laser-induced postionization-Reference-Cited by-同舟云学术

Mass spectrometry imaging with laser-induced postionization

Published:2015-04-10 Issue:6231 Volume:348 Page:211-215
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Soltwisch Jens¹,Kettling Hans¹²,Vens-Cappell Simeon¹²,Wiegelmann Marcel¹,Müthing Johannes¹,Dreisewerd Klaus¹²

Affiliation:

1. Institute for Hygiene, University of Münster, Robert-Koch-Strasse 41, 48149 Münster, Germany.

2. Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Domagkstrasse 3, 48149 Münster, Germany.

Abstract

Imaging lipid composition Chemical imaging of cell membranes can be performed with matrix-assisted laser desorption/ionization mass spectrometry (MALDI), but low ionization efficiency often leads to a signal dominated by the main lipid components, such as abundant phosphatidylcholine species. Soltwisch et al. used a tunable laser for post-ionization of neutral species to boost the signal for other membrane components, such as cholesterol and phospho- and glycolipids. Imaging of cells and tissues with these methods allows differentiation based on a more extensive chemical signature. Science , this issue p. 211

Funder

German Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

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