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2. Mirra S. S., Hart M. N., Terry R. D., Arch. Pathol. Lab. Med. 117, 132 (1993).
3. A panel of neuropathologists convened by the National Institute on Aging and the Ronald and Nancy Reagan Institute of the Alzheimer's Association recently developed a set of recommendations for postmortem diagnosis of AD [ Neurobiol. Aging in press]. There are several key points made in this important document among them that neurofibrillary pathology occurs in a limited fashion in many aged individuals that do not have dementia. Also the degree to which these pathologic changes are diagnostic of AD is dependent on their regional location and density. Thus given that NFT and neuropil threads can be present in neurologically normal individuals and that their distribution and density constitute a more reliable correlate of AD than their absolute presence or absence we prefer to consider such profiles as reflecting neurofibrillary pathology rather than referring to them as AD-related changes or AD lesions.
4. P. R. Hof and J. H. Morrison in Alzheimer Disease R. D. Terry R. Katzman K. L. Bick Eds. (Raven New York 1994) pp. 197-229
5. J. Am. Geriatr. Soc. 44 857 (1996);