Human DNA Repair Genes-Reference-Cited by-同舟云学术

Human DNA Repair Genes

Published:2001-02-16 Issue:5507 Volume:291 Page:1284-1289
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wood Richard D.¹,Mitchell Michael²,Sgouros John²,Lindahl Tomas¹

Affiliation:

1. Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK.

2. Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Abstract

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Quality Control by DNA Repair

2. The data in this paper were based on searches of the Ensembl sequence data freeze of 17 July 2000 and analysis updates as of 13 December 2000; seewww.ensembl.org. Additional data were from the Golden Path server at the University of California at Santa Cruz (). Expressed sequence tag (EST) searches used dbEST [

3. Boguski M. S., Lowe T. M., Tolstoshev C. M., Nature Genet. 4, 332 (1993)].

4. Eisen J. A., Hanawalt P. C., Mutat. Res. DNA Repair 435, 171 (1999).

5. Aravind L., Walker D. R., Koonin E. V., Nucleic Acids Res. 27, 1223 (1999).

Cited by 1081 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Worldwide analysis of actionable genomic alterations in lung cancer and targeted pharmacogenomic strategies;Heliyon;2024-09

2. Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia;The American Journal of Human Genetics;2024-09

3. Psoriatic skin transcript phenotype: androgen/estrogen and cortisone/cortisol imbalance with increasing DNA damage response;Molecular Biology Reports;2024-08-24

4. Rare Germline Variants in DNA Repair Genes Detected in BRCA-Negative Finnish Patients with Early-Onset Breast Cancer;Cancers;2024-08-24

5. Genetic and Epigenetic Biomarkers Associated with Early Relapse in Pediatric Acute Lymphoblastic Leukemia: A Focused Bioinformatics Study on DNA-Repair Genes;Biomedicines;2024-08-05