Generalized Potential of Adult Neural Stem Cells-Reference-Cited by-同舟云学术

Generalized Potential of Adult Neural Stem Cells

Published:2000-06-02 Issue:5471 Volume:288 Page:1660-1663
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Clarke Diana L.¹,Johansson Clas B.¹²,Wilbertz Johannes¹,Veress Biborka¹,Nilsson Erik¹,Karlström Helena¹,Lendahl Urban¹,Frisén Jonas¹

Affiliation:

1. Department of Cell and Molecular Biology, Medical Nobel Institute, and

2. Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Abstract

The differentiation potential of stem cells in tissues of the adult has been thought to be limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Stem Cells in the Central Nervous System

2. CNS stem cells: Where's the biology (a.k.a. beef)?

3. Get to know your stem cells

4. The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease

5. Stem cells in the adult mammalian central nervous system

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