Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer

Author:

Akhtar-Zaidi Batool12,Cowper-Sal·lari Richard3,Corradin Olivia1,Saiakhova Alina1,Bartels Cynthia F.1,Balasubramanian Dheepa1,Myeroff Lois4,Lutterbaugh James4,Jarrar Awad5,Kalady Matthew F.456,Willis Joseph47,Moore Jason H.3,Tesar Paul J.14,Laframboise Thomas14,Markowitz Sanford148,Lupien Mathieu39,Scacheri Peter C.124

Affiliation:

1. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

2. Department of Molecular Medicine of the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

3. Norris Cotton Cancer Center, Institute for Quantitative Biomedical Sciences, Department of Genetics, Dartmouth Medical School, Lebanon, NH 03756, USA.

4. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

5. Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

6. Cancer Biology Department, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

7. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

9. Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, USA.

Abstract

Colorectal Cancer Signature The mutations and genome aberrations that characterize cancer result in often dramatically altered gene and protein expression patterns. It is these altered expression patterns that directly and indirectly drive progression of the disease. In human primary colorectal cancer cells, Akhtar-Zaidi et al. (p. 736 , published online 12 April) analyzed the pattern of epigenetically modified chromatin at “enhancer” sequences that are known to be critical in the control of gene expression. An epigenetic enhancer signature was defined that was specifically associated with colorectal cancer cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 289 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3