Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells-Reference-Cited by-同舟云学术

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Published:2018-05-25 Issue:6391 Volume:360 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ma Chi¹^ORCID,Han Miaojun¹,Heinrich Bernd¹^ORCID,Fu Qiong¹^ORCID,Zhang Qianfei¹,Sandhu Milan¹,Agdashian David¹^ORCID,Terabe Masaki²^ORCID,Berzofsky Jay A.²^ORCID,Fako Valerie³^ORCID,Ritz Thomas⁴,Longerich Thomas⁴⁵,Theriot Casey M.⁶,McCulloch John A.⁷,Roy Soumen⁷,Yuan Wuxing⁷⁸,Thovarai Vishal⁷⁸^ORCID,Sen Shurjo K.⁷⁸^ORCID,Ruchirawat Mathuros⁹^ORCID,Korangy Firouzeh¹,Wang Xin Wei³¹⁰,Trinchieri Giorgio⁷,Greten Tim F.¹¹⁰^ORCID

Affiliation:

1. Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

2. Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

3. Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

4. Institute of Pathology, University Hospital RWTH Aachen, Aachen 52074, Germany.

5. Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany.

6. Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.

7. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

8. Leidos Biomedical Research, Inc, Microbiome Sequencing Core, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

9. Chulabhorn Research Institute, Bangkok, Thailand.

10. NCI CCR Liver Cancer Program, Bethesda, MD, USA.

Abstract

Bile acids and liver cancer Liver cancer is a leading cause of cancer-related deaths in the United States. The composition of the gut microbiome influences many human diseases, including liver inflammatory disorders. Ma et al. found that commensal gut bacteria can recruit the immune system to control the growth of liver tumors in mice (see the Perspective by Hartmann and Kronenberg). Clostridium species modified bile acids to signal liver sinusoidal endothelial cells to produce the chemokine CXCL16. This recruited natural killer T (NKT) immune cells to perform antitumor surveillance of the liver. Growth of both primary and metastatic cancer was reduced by NKT cell–driven killing. Science , this issue p. eaan5931 ; see also p. 858

Funder

National Institutes of Health

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

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