Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ-Reference-Cited by-同舟云学术

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

Published:2020-12-04 Issue:6521 Volume:370 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Martin Raoul¹²^ORCID,Qi Tiancong³⁴^ORCID,Zhang Haibo³^ORCID,Liu Furong⁵^ORCID,King Miles⁵,Toth Claire⁶^ORCID,Nogales Eva²⁶⁷⁸^ORCID,Staskawicz Brian J.⁴⁵^ORCID

Affiliation:

1. Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.

2. QB3, University of California, Berkeley, CA 94720, USA.

3. Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

4. Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 USA.

5. Innovative Genomics Institute, University of California, Berkeley, CA 94720 USA.

6. Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA.

7. Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

8. Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.

Abstract

Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (TIR) domains (TIR-NLRs) (see the Perspective by Tian and Li). Ma et al. studied the Arabidopsis thaliana TIR-NLR RPP1 (recognition of Peronospora parasitica 1) and its response to effectors from an oomycete pathogen. Martin et al. studied the Nicotiana benthamiana TIR-NLR ROQ1 (recognition of XopQ 1) and its response to the Xanthomonas effector. Both groups found that these TIR-NLRs formed tetramers that, when activated by binding to the pathogen effector, exposed the active site of a nicotinamide adenine dinucleoside (NAD) hydrolase. Thus, recognition of the pathogen effector initiates NAD hydrolysis and begins the immune response. Science , this issue p. eabe3069 , p. eabd9993 ; see also p. 1163

Funder

Howard Hughes Medical Institute

IGI Director’s Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

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2. Structural Insights into the Plant Immune Receptors PRRs and NLRs

3. Evolution of Plant NLRs: From Natural History to Precise Modifications

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5. Help wanted: helper NLRs and plant immune responses

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