Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin-Reference-Cited by-同舟云学术

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

Published:2018-11-02 Issue:6414 Volume:362 Page:598-602
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Laursen Nick S.¹^ORCID,Friesen Robert H. E.²,Zhu Xueyong¹,Jongeneelen Mandy³,Blokland Sven³,Vermond Jan⁴^ORCID,van Eijgen Alida⁴,Tang Chan³^ORCID,van Diepen Harry⁴^ORCID,Obmolova Galina²^ORCID,van der Neut Kolfschoten Marijn³^ORCID,Zuijdgeest David³^ORCID,Straetemans Roel⁵,Hoffman Ryan M. B.¹,Nieusma Travis¹,Pallesen Jesper¹^ORCID,Turner Hannah L.¹,Bernard Steffen M.¹,Ward Andrew B.¹^ORCID,Luo Jinquan²,Poon Leo L. M.⁶,Tretiakova Anna P.⁷,Wilson James M.⁷^ORCID,Limberis Maria P.⁷,Vogels Ronald³,Brandenburg Boerries³^ORCID,Kolkman Joost A.⁸^ORCID,Wilson Ian A.¹⁹^ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Janssen Research and Development, Spring House, PA 19002, USA.

3. Janssen Vaccines and Prevention, Archimedesweg 4-6, 2333 CN, Leiden, Netherlands.

4. Janssen Prevention Center, Archimedesweg 6, 2333 CN, Leiden, Netherlands.

5. Quantitative Sciences, Janssen Pharmaceutical Companies of Johnson and Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.

6. Center of Influenza Research and School of Public Health, The University of Hong Kong, Hong Kong SAR, China.

7. Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

8. Janssen Infectious Diseases, Turnhoutseweg 30, 2340, Beerse, Belgium.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Durable influenza protection Vaccines are indispensable for the control and prevention of influenza, but there are several challenges to efficacy. Some individuals respond poorly to vaccination, and virus variation makes targeting optimal antigens difficult. Broadly neutralizing antibodies are one solution, but they have their own pitfalls, including limited cross-reactivity to both influenza A and B strains and the need for repeated injections. Now, Laursen et al. have developed multidomain antibodies with breadth and potency. Administered intranasally to mice with an adeno-associated virus vector, the antibodies provided durable and continuous protection from a panoply of influenza strains. Science , this issue p. 598

Funder

National Institutes of Health

Research Grants Council, University Grants Committee, Hong Kong

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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