Somatic mutation in single human neurons tracks developmental and transcriptional history

Author:

Lodato Michael A.1,Woodworth Mollie B.1,Lee Semin2,Evrony Gilad D.1,Mehta Bhaven K.1,Karger Amir3,Lee Soohyun2,Chittenden Thomas W.34,D’Gama Alissa M.1,Cai Xuyu1,Luquette Lovelace J.2,Lee Eunjung25,Park Peter J.25,Walsh Christopher A.1

Affiliation:

1. Division of Genetics and Genomics, Manton Center for Orphan Disease, and Howard Hughes Medical Institute, Boston Children’s Hospital, Boston, MA, USA; Departments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA; and Broad Institute of MIT and Harvard, Cambridge, MA, USA.

2. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

3. Research Computing, Harvard Medical School, Boston, MA, USA.

4. Complex Biological Systems Alliance, North Andover, MA, USA.

5. Division of Genetics, Brigham and Women’s Hospital, Boston, MA, USA.

Abstract

Individualized neuronal mutations in the human brain The neurons of the human brain can last for decades, carrying out computational and signaling functions. Lodato et al. analyzed the DNA of individual neurons sampled from postmortem human brains and found that individual neurons acquired somatic mutations (see the Perspective by Linnarsson). The mechanism of mutation involved gene transcription rather than DNA replication. Thus, postmitotic neurons would seem to be their own worst enemy: Genes used for neuronal function are the very genes put most at risk of somatic mutation. Science , this issue p. 94 ; see also p. 37

Funder

Howard Hughes Medical Institute

National Institute of Mental Health

National Institute on Aging

National Institute of General Medical Sciences (NIGMS)

NIGMS

National Institute of Neurological Disorders and Stroke

National Center for Research Resources

Paul G. Allen Family Foundation

Leonard and Isabelle Goldenson Research Fellowship

Louis Lange III Scholarship in Translational Research

Eleanor and Miles Shore Fellowship

Manton Center for Orphan Disease Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 486 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3