Rapid Pneumococcal Evolution in Response to Clinical Interventions

Author:

Croucher Nicholas J.1,Harris Simon R.1,Fraser Christophe2,Quail Michael A.1,Burton John1,van der Linden Mark3,McGee Lesley4,von Gottberg Anne5,Song Jae Hoon6,Ko Kwan Soo7,Pichon Bruno8,Baker Stephen9,Parry Christopher M.9,Lambertsen Lotte M.10,Shahinas Dea11,Pillai Dylan R.11,Mitchell Timothy J.12,Dougan Gordon1,Tomasz Alexander13,Klugman Keith P.4514,Parkhill Julian1,Hanage William P.215,Bentley Stephen D.1

Affiliation:

1. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Department of Infectious Disease Epidemiology, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK.

3. Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.

4. Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

5. Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases of the National Health Laboratory Service and University of Witwatersrand, Johannesburg 2000, South Africa.

6. Samsung Medical Centre, Sungkyunkwan University School of Medicine and Asia Pacific Foundation for Infectious Disease, Seoul, South Korea.

7. Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, South Korea.

8. Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, London NW9 5HT, UK.

9. The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

10. Department of Microbiological Surveillance and Research, Statens Serum Institut, 2300 Copenhagen S, Denmark.

11. Department of Laboratory Medicine and Pathobiology, University of Toronto and Ontario Agency for Health Protection and Promotion, Toronto, Ontario, M5G 1V2, Canada.

12. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.

13. Laboratory of Microbiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

14. Hubert Department of Global Health, Rollins School of Public Health. and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, GA 30322, USA.

15. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

Abstract

Streptococcus pneumonia evades vaccines and drugs by high levels of recombination and rapid adaptation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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