Structural insight into precursor tRNA processing by yeast ribonuclease P-Reference-Cited by-同舟云学术

Structural insight into precursor tRNA processing by yeast ribonuclease P

Published:2018-11-09 Issue:6415 Volume:362 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lan Pengfei¹^ORCID,Tan Ming²³^ORCID,Zhang Yuebin⁴^ORCID,Niu Shuangshuang²³⁵^ORCID,Chen Juan¹,Shi Shaohua¹,Qiu Shuwan⁶,Wang Xuejuan⁶^ORCID,Peng Xiangda⁴^ORCID,Cai Gang⁶^ORCID,Cheng Hong²,Wu Jian¹^ORCID,Li Guohui⁴^ORCID,Lei Ming¹⁷⁸⁹^ORCID

Affiliation:

1. Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China.

2. State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai 200031, China.

3. University of Chinese Academy of Sciences, CAS, Shanghai 200031, China.

4. Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, CAS, Dalian 116023, China.

5. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

6. Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

7. Key laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

8. National Facility for Protein Science in Shanghai, Zhangjiang Laboratory, Shanghai, 201210, China.

9. Shanghai Science Research Center, CAS, Shanghai, 201204, China.

Abstract

Structures of eukaryotic ribonuclease P Ribonuclease P (RNase P) is a ribozyme that processes transfer RNA (tRNA) precursors and is found in all three kingdoms of life. Now, Lan et al. report the structures of yeast RNase P (see the Perspective by Scott and Nagai). The aporibozyme structure reveals how the protein components stabilize the RNA and explains how the structural roles of bacterial RNA elements have been delegated to the protein components in RNase P of higher organisms during evolution. The structure of yeast RNase P in complex with its natural substrate, a tRNA precursor, demonstrates the structural basis for substrate recognition and provides insights into its catalytic mechanism. Science , this issue p. eaat6678 ; see also p. 644

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference101 articles.

1. S. Altman L. A. Kirsebom in Ribonuclease P: In The RNA World R. Gesteland T. Cech J. Atkins Eds. (Cold Spring Harbor Laboratory Press ed. 2 1999) chap. 14 pp. 351–378.

2. Of proteins and RNA: The RNase P/MRP family

3. RNase P: interface of the RNA and protein worlds

4. Ribonuclease P: The Evolution of an Ancient RNA Enzyme

5. Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The specificity landscape of bacterial ribonuclease P;Journal of Biological Chemistry;2024-01

2. Recognition of the tRNA structure: Everything everywhere but not all at once;Cell Chemical Biology;2024-01

3. Scaffold RNA engineering in type V CRISPR-Cas systems: a potent way to enhance gene expression in the yeast Saccharomyces cerevisiae;Nucleic Acids Research;2023-12-24

4. Bacterial RNA-free RNase P: Structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P;Journal of Biological Chemistry;2023-11

5. Importance of residue 248 in Escherichia coli RNase P RNA mediated cleavage;Scientific Reports;2023-08-29