Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir-Reference-Cited by-同舟云学术

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Published:2020-06-26 Issue:6498 Volume:368 Page:1499-1504
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yin Wanchao¹²^ORCID,Mao Chunyou²,Luan Xiaodong³⁴⁵^ORCID,Shen Dan-Dan²^ORCID,Shen Qingya²^ORCID,Su Haixia¹⁶^ORCID,Wang Xiaoxi¹^ORCID,Zhou Fulai¹^ORCID,Zhao Wenfeng¹^ORCID,Gao Minqi⁷^ORCID,Chang Shenghai⁸⁹^ORCID,Xie Yuan-Chao¹^ORCID,Tian Guanghui¹^ORCID,Jiang He-Wei¹⁰,Tao Sheng-Ce¹⁰^ORCID,Shen Jingshan¹⁶^ORCID,Jiang Yi¹⁶^ORCID,Jiang Hualiang¹⁶^ORCID,Xu Yechun¹⁶^ORCID,Zhang Shuyang³⁴⁵^ORCID,Zhang Yan²¹¹^ORCID,Xu H. Eric¹⁶^ORCID

Affiliation:

1. The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

2. Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

3. School of Medicine, Tsinghua University, Haidian District, Beijing 100084, China.

4. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.

5. Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

6. University of Chinese Academy of Sciences, Beijing 100049, China.

7. WuxiBiortus Biosciences Co. Ltd., Jiangyin 214437, China.

8. Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou 310058, China.

9. Center of Diagnostic Electron Microscopy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.

10. Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China.

11. Key Laboratory of Immunity and Inflammatory Diseases of Zhejiang Province, Hangzhou 310058, China.

Abstract

A wrench in the works of COVID-19 Understanding the inner workings of the virus that causes coronavirus disease 2019 (COVID-19) may help us to disrupt it. Yin et al. focused on the viral polymerase essential for replicating viral RNA. They determined a structure of the polymerase bound to RNA and to the drug remdesivir. Remdesivir mimics an RNA nucleotide building block and is covalently linked to the replicating RNA, which blocks further synthesis of RNA. The structure provides a template for designing improved therapeutics against the viral polymerase. Science , this issue p. 1499

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

National Science Foundation of China

National Science and Technology Major Project

Shanghai Municipal Science and Technology Major Project

Jack Ma Foundation

CAMS Innovation Fund for "13th Five-Year" National Science and Technology Major Project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary