Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia-Reference-Cited by-同舟云学术

Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia

Published:2007-02-23 Issue:5815 Volume:315 Page:1130-1133
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Labandeira-Rey Maria¹²³⁴⁵,Couzon Florence¹²³⁴⁵,Boisset Sandrine¹²³⁴⁵,Brown Eric L.¹²³⁴⁵,Bes Michele¹²³⁴⁵,Benito Yvonne¹²³⁴⁵,Barbu Elena M.¹²³⁴⁵,Vazquez Vanessa¹²³⁴⁵,Höök Magnus¹²³⁴⁵,Etienne Jerome¹²³⁴⁵,Vandenesch François¹²³⁴⁵,Bowden M. Gabriela¹²³⁴⁵

Affiliation:

1. Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, The Texas A&M University System Health Science Center, Houston, TX 77030, USA.

2. Université de Lyon, Lyon, F-69008, France.

3. Université de Lyon 1, Faculté Laennec, Lyon, F-69008, France.

4. INSERM E0230, Centre National de référence des staphylocoques, Lyon, F-69008, France.

5. Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, F-69003, France.

Abstract

The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model. Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall–anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

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4. Community-Associated MRSA — Resistance and Virulence Converge

5. P. N. Panton, M. C. Camb, F. C. O. Valentine, M. R. C. P. Lond, Lancet1, 506 (1932).

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