The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production-Reference-Cited by-同舟云学术

The Structural Basis of Pathogenic Subgenomic Flavivirus RNA (sfRNA) Production

Published:2014-04-18 Issue:6181 Volume:344 Page:307-310
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chapman Erich G.¹²,Costantino David A.¹²,Rabe Jennifer L.¹,Moon Stephanie L.³,Wilusz Jeffrey³,Nix Jay C.⁴,Kieft Jeffrey S.¹²

Affiliation:

1. Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

2. Howard Hughes Medical Institute, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

3. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

4. Molecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

Resisting the Chop Dengue, West Nile, and Yellow Fever viruses are all flaviviruses that have single-stranded RNA genomes and form specific, short flaviviral RNAs (sfRNAs) during infection that cause viral pathogenicity. These sfRNAs are produced by the incomplete degradation of viral RNA by the host-cell exonuclease Xrn1. What stops the host enzyme from completely chopping up the viral RNA? Chapman et al. (p. 307 ) reveal a pseudoknot in the structure of the Xrn1-resistant segment of a sfRNA from Murray Valley Encephalitis Virus, which, perhaps, the host Xrn1 exonuclease cannot untangle.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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