Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22-Reference-Cited by-同舟云学术

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

Published:2000-04-28 Issue:5466 Volume:288 Page:678-682
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Brzustowicz Linda M.¹²,Hodgkinson Kathleen A.³,Chow Eva W. C.³⁴,Honer William G.⁵,Bassett Anne S.³⁴

Affiliation:

1. Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.

2. Department of Psychiatry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.

3. Genetics Section, Schizophrenia Research Program, Centre for Addiction and Mental Health, Queen Street Division, and

4. Department of Psychiatry, University of Toronto, Toronto M6J 1H4, Canada.

5. Department of Psychiatry, University of British Columbia, Vancouver V6H 3Z6, Canada.

Abstract

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. The Strength of the Genetic Effect

2. Risch N., Am. J. Hum. Genet. 46, 222 (1990).

3. R. E. Straub C. J. MacLean F. A. O'Neill

4. Support for a possible schizophrenia vulnerability locus in region 5q22–31 in Irish families

5. Genomic scan for genes predisposing to schizophrenia

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