Microglia: Scapegoat, Saboteur, or Something Else?-Reference-Cited by-同舟云学术

Microglia: Scapegoat, Saboteur, or Something Else?

Published:2013-01-11 Issue:6116 Volume:339 Page:156-161
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Aguzzi Adriano¹,Barres Ben A.²,Bennett Mariko L.²

Affiliation:

1. Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8012 Zurich, Switzerland.

2. Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases and injuries. Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases. It also seems increasingly likely that microglial dysfunction can underlie certain neurological diseases without an obvious immune component.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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