Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

Author:

Bouziat Romain12ORCID,Hinterleitner Reinhard12ORCID,Brown Judy J.34ORCID,Stencel-Baerenwald Jennifer E.34,Ikizler Mine45,Mayassi Toufic12ORCID,Meisel Marlies12,Kim Sangman M.12ORCID,Discepolo Valentina16ORCID,Pruijssers Andrea J.45,Ernest Jordan D.12ORCID,Iskarpatyoti Jason A.45,Costes Léa M. M.17,Lawrence Ian12ORCID,Palanski Brad A.8ORCID,Varma Mukund910ORCID,Zurenski Matthew A.12,Khomandiak Solomiia45,McAllister Nicole34ORCID,Aravamudhan Pavithra45,Boehme Karl W.45ORCID,Hu Fengling1,Samsom Janneke N.7,Reinecker Hans-Christian9ORCID,Kupfer Sonia S.111,Guandalini Stefano1112,Semrad Carol E.111,Abadie Valérie13,Khosla Chaitan81415,Barreiro Luis B.16ORCID,Xavier Ramnik J.91017ORCID,Ng Aylwin910,Dermody Terence S.3451819ORCID,Jabri Bana12111220ORCID

Affiliation:

1. Department of Medicine, University of Chicago, Chicago, IL, USA.

2. Committee on Immunology, University of Chicago, Chicago, IL, USA.

3. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

4. Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.

5. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

6. Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, and CeInGe–Biotecnologie Avanzate, Naples, Italy.

7. Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, Netherlands.

8. Department of Chemistry, Stanford University, Stanford, CA, USA.

9. Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

10. Broad Institute of MIT and Harvard University, Cambridge, MA, USA.

11. University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.

12. Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.

13. Department of Microbiology, Infectiology, and Immunology, University of Montreal, and the Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montreal, Quebec, Canada.

14. Department of Chemical Engineering, Stanford University, Stanford, CA, USA.

15. Stanford ChEM-H, Stanford University, Stanford, California, USA.

16. Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.

17. Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

18. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

19. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

20. Department of Pathology, University of Chicago, Chicago, IL, USA.

Abstract

A nonpathogenic virus can promote inflammatory immunity to dietary antigens and may be linked to the development of celiac disease.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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