Toward an AIDS Vaccine-Reference-Cited by-同舟云学术

Toward an AIDS Vaccine

Published:2008-05-09 Issue:5877 Volume:320 Page:760-764
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Walker Bruce D.¹²³,Burton Dennis R.¹²³

Affiliation:

1. Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

2. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

3. The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus, including the extreme genetic variability in circulating viral isolates worldwide, biological properties of HIV that impede immune attack, and a high mutation rate that allows for rapid escape from adaptive immune responses, render this a huge challenge. However, evidence of protection against AIDS viruses in animal models and control of HIV in humans under certain circumstances, together with scientific advances in understanding disease pathogenesis, provide a strong rationale and objective paths to continue the pursuit of an effective AIDS vaccine to stem the global epidemic.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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3. Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

4. Serological Analysis of a Subgroup of Human T-Lymphotropic Retroviruses (HTLV-III) Associated with AIDS

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