Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

Author:

Nguyen Dao1,Joshi-Datar Amruta2,Lepine Francois3,Bauerle Elizabeth2,Olakanmi Oyebode4,Beer Karlyn2,McKay Geoffrey1,Siehnel Richard2,Schafhauser James1,Wang Yun5,Britigan Bradley E.46,Singh Pradeep K.2

Affiliation:

1. Departments of Medicine, Microbiology and Immunology,McGill University, 1650 Cedar Avenue, L11.513, Montreal, Quebec H3G 1A4, Canada.

2. Departments of Medicine and Microbiology, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98195–7242, USA.

3. Department of Microbiology, INRS Armand Frappier, 531 Boulevarde des Prairies, Laval, Quebec H7V 1B7, Canada.

4. Department of Internal Medicine, University of Cincinnati, Medical Sciences Building 6065, Post Office Box 670557, Cincinnati, OH 45267, USA.

5. Department of Civil and Environmental Engineering, Northwestern University, A222 Technological Institute, 2145 Sheridan Road, Evanston, IL 60208, USA.

6. Veterans Administration Medical Center–Cincinnati, 3200 Vine Street, Cincinnati, OH 45220, USA.

Abstract

During growth arrest, bacteria tolerate the presence of antibiotics, thanks to mechanisms that protect against oxidant stress.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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